MyMD Pharmaceuticals Enrolls First Patient in Stage 2 Clinical Test of MYMD-1 as a Treatment for Delaying Aging and also Increasing Healthy And Balanced Lifespan

MyMD Pharmaceuticals, Inc. MYMD stock price (” MyMD” or “the Business”), a scientific phase pharmaceutical firm devoted to expanding healthy life-span, today introduced that the initial person has actually been signed up in the Firm’s Stage 2 professional test of lead candidate MYMD-1, a dental immune regulatory authority medicine, as a treatment for delaying aging as well as increasing healthy life-span.

The primary endpoint for the Phase 2 double-blind, placebo-controlled clinical trial is to attain a decrease in the flowing levels of (TNF-α), lump death factor receptor I (TNFRI) and also IL-6. TNF-α and also IL-6 are the proteins in the body that create swelling and also assist turn on the procedure of aging. The second measures of the trial will certainly be the safety and security, tolerability, and also pharmacokinetics in this population of people.

” In a Phase 1 medical trial of MYMD-1, we demonstrated the medicine’s statistically considerable effectiveness in minimizing degrees of TNF-α, a principal in causing pathological aging, in the blood. The FDA has actually authorized TNF-α reduction as the primary endpoint for our Phase 2 research study, which our company believe settings us well for a successful Phase 2 end result,” claimed Chris Chapman, M.D., Head Of State, Supervisor and Principal Medical Policeman of MyMD. “The initiation of individual enrollment in this study developments our objective to reduce the aging procedure, avoid loss of muscle mass tissue in aging, limit frailty, and also expand healthy and balanced life expectancy.”

MyMD has specified that there are no FDA-approved medications for treating aging conditions and expanding healthy and balanced life-span humans, a market expected to be at least $600 billion by 20251 according to a major financial investment financial institution. TNF-α blockers are the most proposed drugs by earnings, a worldwide market of about $40 billion annually,2 and, according to Nature Aging journal,3 a slowdown in maturing that would certainly raise life span by one year is worth $38 trillion as well as by one decade deserves $367 trillion.

In addition to aging, MYMD-1’s distinctive activity in controling the immune system and dealing with persistent inflammation is being established for the therapy of autoimmune illness, including rheumatoid joint inflammation (RA), multiple sclerosis (MS), diabetic issues, as well as inflammatory bowel illness.

” We intend to start writing methods for a Phase 2 pilot study of MYMD-1 for rheumatoid joint inflammation early this year,” Dr. Chapman kept in mind. “The climbing occurrence of rheumatoid arthritis as well as various other autoimmune and inflammatory conditions are driving need for TNF inhibitors like MYMD-1, as well as our company believe our by mouth carried out drug with very reduced poisoning would be disruptive to the $60 billion market for RA if authorized by the FDA for this indication.”

Rheumatoid joint inflammation influences about 40 million people globally.4.

Regarding MYMD-1.

Initially developed for autoimmune illness, MYMD-1’s main objective is to slow down the aging process, avoid sarcopenia and also frailty, and prolong healthy and balanced life-span. Due to the fact that it can go across the blood-brain obstacle as well as get to the main nervous system (CNS), MYMD-1 is additionally positioned to be a feasible treatment for brain-related conditions. Its system of activity and efficiency in illness including multiple sclerosis (MS) and thyroiditis have been researched through partnerships with a number of academic establishments. MYMD-1 is additionally showing promise in pre-clinical research studies as a possible treatment for post- COVID-19 problems and as an anti-fibrotic as well as anti-proliferation healing.

MYMD-1 has actually shown performance in pre-clinical studies in controling the body immune system by doing as a careful inhibitor of lump necrosis factor-alpha (TNF-α), a driver of chronic inflammation. Unlike various other treatments, MYMD-1 has actually been displayed in these pre-clinical research studies to precisely block TNF-α when it comes to be overactivated in autoimmune diseases as well as cytokine tornados, however not obstruct it from doing its regular task of being a very first responder to any type of routine type of modest infection. MYMD-1’s convenience of dental application is an additional differentiator contrasted to currently readily available TNF-α blockers, every one of which need delivery by shot or infusion. No accepted TNF prevention has ever before been dosed orally. On top of that, the medicine is not immunosuppressive and also has not been revealed to trigger the significant negative effects usual with traditional therapies that treat swelling.

Regarding MyMD Pharmaceuticals, Inc

. MyMD Pharmaceuticals, Inc. (Nasdaq: MYMD), a medical stage pharmaceutical business dedicated to extending healthy and balanced lifespan, is focused on developing 2 novel therapeutic platforms that treat the root causes of illness rather than just resolving the signs and symptoms. MYMD-1 is a medication platform based upon a medical phase small molecule that regulates the body immune system to regulate TNF-α, which drives chronic inflammation, and also various other pro-inflammatory cell signaling cytokines. MYMD-1 is being created to postpone aging, rise long life, and deal with autoimmune conditions and COVID-19- linked clinical depression. The Company’s 2nd medicine system, Supera-CBD, is being created to treat persistent discomfort, addiction as well as epilepsy. Supera-CBD is an unique artificial derivative of cannabidiol (CBD) as well as is being developed to resolve as well as surpass the quickly expanding CBD market, which includes both FDA authorized medications and also CBD products not currently regulated as medicines. To learn more, browse through www.mymd.com.

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